Dembele has not played since rupturing a tendon against Getafe in September, initially ruling him out for four months.
Pique said he could understand that Brazilian wanted to seek new challenges and win the Ballon d'Or.
Eduardo Berizzo's return to the Sevilla dugout delivered some defensive steel but no cutting edge up front as Levante ground out a goalless draw.
Barcelona winger Gerard Deulofeu has been ruled out for the next 10 days with a knee problem.
From the bertso derbia off the pitch to events on it, Saturday's showdown means a great deal, not least to two clubs struggling for their best form.
Antoine Griezmann will be allowed to leave Atletico Madrid if the right opportunity comes along for the France forward, according to Diego Simeone.
Gremio's president says Barcelona have not made an offer for midfielder Arthur, who appeared in leaked images wearing their shirt.
Valencia general director Mateu Alemany expects Andreas Pereira to remain at the club until at least next summer.
Colombia international James Rodriguez is not looking too far ahead and says he is just happy to be receiving regular playing time at Bayern Munich.
Cristiano Ronaldo has spoken of his "pride" in recent individual achievements, including a fifth career Ballon d'Or trophy.
Manchester City have claimed the Premier League's longest winning streak -- now they have the record across Europe's top five leagues in their sights.
La Liga president Javier Tebas has defended the decision that has led to Valencia's home game against Girona being played on Spain's Three Kings' Day.
Gareth Bale took his first steps on the road to redemption with his Club World Cup rescue act but can the Real Madrid star fully turn his doubters?
Ex-Real Madrid midfielder Xabi Alonso has explained how Jose Mourinho's teams can be "in control" of games without dominating possession.
Mentioning Thomas Vermaelen often elicits jeers and sarcasm but the injury-bitten Barca defender is showing he's more than an emergency option.
Andres Iniesta says he would be annoyed if former teammate Neymar left Paris Saint-Germain for Barcelona's rivals Real Madrid.
Yerry Mina's agent says there has not yet been any contact from Barcelona regarding a January move for the Palmeiras centre-back.
Barcelona's Nelson Semedo says he understood Neymar was going through a difficult moment when the two clashed in preseason.
Zlatan Ibrahimovic says Manchester City coach Pep Guardiola is the most "immature" person he has ever worked under.
Real Madrid vice-captain Marcelo says fear of being suspended for the Clasico will not make him pull out of tackles at this week's Club World Cup.