A list of the clubs left in the fight reads like a "Who's Who" of the history of South American football.
Brazilian and Argentine clubs ruled the group stage, but when the tournament resumes after the World Cup, expect one nation to have the upper hand.
Corinthians donated $3,000 to hotel staffers in Venezuela before their Copa Libertadores match because of the economic crisis in the country.
Clubs from Brazil and Argentina could account for up to 12 of the representatives in the knockout rounds of the Copa Libertadores.
The Copa Libertadores has reached a fascinating stage and it's a make-or-break week, with Boca Juniors' hopes in the balance.
The 17-year-old Paulinho has been picking up invaluable first-team experience with Vasco. In Germany he may well have to be more patient.
One of the early trends in this year's Copa Libertadores is that players are getting a chance to audition for European clubs and World Cup spots.
A Boca-Palmeiras match usually takes place later in the Copa Libertadores, but the two South American powers will go head-to-head in the group stage.
Thursday's meeting between the Argentine and Brazilian powers harks back to the days when South America's premier tournament captivated the world.
Vinicius Junior came on with a match-winning brace for Flamengo in the Copa Libertadores - and it will be just as thrilling to Real Madrid supporters.
The first week of the Copa Libertadores group stage brought surprising upsets, struggles for Brazilian clubs and the emergence of an Argentine star.
There is an inevitability to the Copa Libertadores, and that feels true once more with 16 former champions in the field, but unpredictability reigns.
The Copa Libertadores will follow the European model in 2019 and have a single final match at a host city still to be chosen.
Don't dismiss the teams vying to make it into the Copa Libertadores as qualifiers. History says that one of them will make a run in the big tourney.
CONMEBOL have fined Nacional and ordered them to play three games behind closed doors after some supporters mocked the Chapecoense plane crash.
Brazil's Chapecoense has been knocked out of the prestigious Copa Libertadores after a surprising qualification for the South American cup last year.
Brazilian football club Chapecoense have asked South America's soccer governing body to expel Uruguayan club Nacional from the Copa Libertadores.
Nacional have apologised after some of their supporters were filmed making plane gestures towards Chapecoense during a Copa Libertadores match.
Deportivo Tachira of Venezuela and Bolivia's Oriente Petrolero, who each had goals in their road matches last week, advanced via the away-goals rule.
The 2018 Copa Libertadores opens this week with a mixture of long-time teams and newcomers hoping to upend the year-long tournament.
Coming just weeks after Gremio took home the 2017 edition, the draw for the 2018 Copa Libertadores features 17 of the competition's 25 winners.
The Court of Arbitration for Sport (CAS) has banned Jose Angulo for four years after he tested positive for cocaine.
In May, Madrid announced that they had signed Vinicius from July 2018, when the Brazil youth international turns 18.
Liga MX clubs are unlikely to rejoin the Copa Libertadores anytime soon, due to the calendar clash between Mexico's first division and the tournament.
A 2-1 victory in the second leg delivered a third Copa Libertadores to Gremio, who would have none of another miracle Lanus comeback.
|Independiente Santa Fe||6||1||4||1||+2||7|
|Vasco da Gama||6||1||2||3||-7||5|
|Universidad de Chile||6||1||2||3||-9||5|
|Estudiantes La Plata||6||2||2||2||+2||8|