One of the international break's standout games sees Brazil meet Argentina, but like many other CONMEBOL nations, both sides are in a state of flux.
Colombia coach Jose Pekerman let his contract run out after six years and two World Cups with the team.
A former head of the governing body for soccer in South America was sentenced to nine years in prison by a U.S. judge on Wednesday.
Venezuela has invested a lot into football in the past decade without much reward. Now, thanks to Deportivo Lara, things are starting to change.
"It's the saddest time in my career. I haven't played the most important games of my life and now I'm not in a final with my club," Guerrero said.
FIFA has suspended Peru captain Paolo Guerrero for a year after the player tested positive for cocaine, meaning he is set to miss the World Cup.
How well do you know the history of World Cup qualification? Test your knowledge ahead of this week's crucial playoffs.
Lionel Messi on suggestions that he runs the Argentina team: "People say a lot of things without knowing. On one hand, it makes me angry."
Peru striker Paolo Guerrero has been provisionally suspended for 30 days after failing a doping test.
More worldwide football tournaments involving potentially all national teams could be coming to every odd-numbered year, under a new proposal.
Former Colombia international Mauricio "Chicho" Serna has been named in a money laundering investigation in Argentina, according to media reports.
The All Whites will play the first leg of their intercontinental World Cup playoff against Peru in Wellington on November 11.
Las Ultimas Noticias published details of Sampaoli's remarks, made in the year that his Chile side won the Copa America on home soil.
The Ecuador Football Federation (FEF) has suspended five national team players indefinitely for indiscipline.
Barcelona defender Javier Mascherano has announced the 2018 World Cup in Russia will be his final tournament with Argentina.
The intercontinental World Cup play offs are now set -- get the full details of the matches.
It was stressful, but ultimately Lionel Messi got Argentina a berth into the 2018 World Cup. So how does the country feel about their team now?
Argentina pulled out a dramatic World Cup qualification and even though there's still joy to be, there's a lot to be fixed, writes Tim Vickery.
Colombia goalkeeper David Ospina says he did not expect Peru's indirect set-piece equaliser to be fired at goal by Paolo Guerrero in the 1-1 draw.
Claudio Bravo says he will take "some time" to decide if he is to continue with Chile after their failure to qualify for the World Cup.
Lionel Messi said "it would have been crazy a World Cup without Argentina" after his dramatic hat trick secured the nation's qualification.