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Philippe Coutinho and Liverpool scored early and never looked back, putting seven past Spartak Moscow on their way to winning Group E.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League round of 16.
Having already sealed top spot in Group H, Tottenham finished off the group stage with a comfortable win over Apoel.
Philippe Coutinho scored a hat trick as Liverpool sealed their place atop Champions League Group E with a runaway 7-0 win.
Manchester City slumped to their first defeat of the season with a 2-1 loss to Shakhtar Donetsk in their final Champions League Group F game.
There are set to be some heavyweight ties in the Champions League round of 16 with the seedings for the first knockout round now known.