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Mahrez returned to action for Leicester when he came on as a substitute in the 62nd minute of the 5-1 defeat at Manchester City on Saturday.
Eden Hazard and Andreas Christensen are pivotal to Antonio Conte's cause as Chelsea chase Champions League and FA Cup glory to salvage a tough season.
United will play for the first time in a game utilising the system when they take on Huddersfield Town in an FA Cup fifth-round tie.
Marcus Rashford injured a hip against Huddersfield Town on Feb. 3 and Manchester United are hoping he'll be fit to face them again on Saturday.
Prince Harry and Meghan Markle's wedding is slated to avoid a clash with the FA Cup final, but Prince William faces a mad dash if he is to attend both
The Crown Oil Arena pitch has been the subject of intense scrutiny this week, with a heavily rutted and sanded surface causing some concern.