Winger Malcom's second-half strike secured Barcelona a 1-1 draw with Real Madrid to leave the Copa del Rey semifinal evenly poised on Wednesday after the first leg.
Vazquez struck after just six minutes to silence the Nou Camp at the end of a slick team move, with Santiago Solari's side impressing in the opening stages.
However, Ivan Rakitic clipped the crossbar with a header as Barcelona fought for an equaliser and Malcom eventually found it when Luis Suarez's shot rebounded to him off the post.
Messi, who suffered a thigh injury at the weekend against Valencia, appeared for the final half hour but could not help champions Barcelona find a late winner.
"Speaking generally, the draw was fair," said Barcelona midfielder Sergio Busquets.
"It was very even, everything will be decided in the second leg. There were chances for both sides to win the game. It's 50-50, even though they're at home.
"The goal will give [Malcom] a lot in terms of confidence, we hope that everyone in the squad can help us."
However, Messi's injury gave him the chance to impress and the 21-year-old was Barcelona's liveliest player, always probing at Madrid's defence.
Wednesday's result would also have gone some way towards healing Real's wounded pride as their last visit to the Nou Camp ended in a 5-1 La Liga thrashing last October in what turned out to be Julen Lopetegui's final game in charge.
"Both sides have the chance to go through," said Madrid goalkeeper Keylor Navas, who made good saves from Suarez and Malcom.
"It was a good game. Everyone on the team worked hard when we needed to and we played well too."
The second leg takes place on Feb. 27 at the Santiago Bernabeu.