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Trailing 3-1 from the first leg, Napoli almost pulled off a stunning comeback over RB Leipzig in the Europa League.
Kevin Gameiro scored Atletico Madrid's only goal as a 1-0 win over Copenhagen was enough to advance from the Europa League round of 32.
Celtic crashed out of the Europa League in calamitous style with a 3-0 defeat to Zenit St Petersburg in Russia.
Napoli crashed out of the Europa League in the round of 32 despite a 1-0 win away to RB Leipzig on Thursday.
Lyon proved to be too much for Villarreal over two legs as they ran out 4-1 aggregate winners and advanced to the Europa League round of 16.
Diego Simeone's Atletico Madrid cruised to the Europa League round of 16 as they defeated Copenhagen 5-1 on aggregate.