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Alexandre Lacazette's knee injury has out a further damper on a disappointing season for the Frenchman but his pain could be Danny Welbeck's gain.
Barca failed with three bids for Coutinho in August, and he remained a Liverpool player when the summer window closed.
Manchester United's problems with aerial assaults have contributed to a run of just six wins from 12 Premier League games since the start of December.
Alvaro Morata missed nearly a month after Chelsea's FA Cup third-round replay against Norwich City because of lingering back pain.
Tottenham partly owe their upturn in fortunes in recent years to "One Of Their Own," in Ryan Mason, who had the knack for scoring important goals.
Arsenal striker Alexandre Lacazette is set to miss up to six weeks through injury after undergoing a knee operation.