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Dortmund drew 0-0 with bottom-club Nurnberg on Monday night with their Bundesliga lead over chasing Bayern Munich now at just three points.
Christian Pulisic sat out Monday's game and is doubtful for another after the Borussia Dortmund midfielder tore a thigh muscle against Spurs.
Borussia Dortmund CEO Hans-Joachim Watzke has dismissed claims that the players' focus was broken ahead of their Champions League defeat at Spurs.
Neither Favre or his Dortmund team are quite the finished article yet, but they showed their inexperience as Spurs hit late goals at Wembley.
Borussia Dortmund midfielder Christian Pulisic was critical of his side's failure to defend crosses against Tottenham.
Tottenham Hotspur will take a commanding lead to the Westfalenstadion next month after beating Borussia Dortmund 3-0 in the Champions League.
England winger Jadon Sancho is happy his move to Borussia Dortmund and subsequent strong performances in the Bundesliga have given English youngster
There are many factors behind Jadon Sancho's stunning rise since moving to Dortmund, but at the heart of it is a player determined to prove himself.
Which eight clubs will make it through to the Champions League quarterfinals? Here are our writers' predictions.
England's younger generation were crowned under-17 and U20 world champions in 2017.
Marco Reus, who has 17 goals for Dortmund in all competitions and is the club's leading scorer, injured his thigh last week.
Borussia Dortmund lost a 3-0 lead against Hoffenheim as they dropped two points in a 3-3 draw that leaves them eight points clear.
Reus, 29, was injured in Dortmund's DFB Pokal defeat to Werder Bremen on Tuesday after scoring an equaliser seconds before half-time.
Jadon Sancho has told ESPN FC that he was inspired to leave Manchester City and join Borussia Dortmund following Christian Pulisic's success.
Rudi Assauer, a former player for Borussia Dortmund and Werder Bremen was recognised as a key figure in German football for his work at Schalke.
Pulisic, 20, told ESPN FC after the game: "We shouldn't have let this game gone to penalty kicks because once you get there anything can happen."
Borussia Dortmund were knocked out of the German Cup by Werder Bremen following a penalty shootout after a thrilling 3-3 draw at home on Tuesday.