ESPN selects the pick of the Afcon group-stage clashes, for various diverse reasons, following Friday's draw in Cairo.
2019 ScheduleAll times ET
At the 2019 Afcon draw, big guns like Egypt and Nigeria got groups some would consider easy, while Group D are the traditional 'Group of Death'.
Some of the continent's less-heralded sides have made the most of the Africa Cup of Nations' expanded format.
Here's the state of play heading into the final round of Africa Cup of Nations qualifiers, with 10 of the 24 berths in the finals up for grabs.
The final round of Africa Cup of Nations qualifiers runs from 22 to 24 March. Which teams have opted to rest some of their biggest stars?
His employers said Ahmed Hussein-Suale, who worked an investigative team that exposed corruption in Ghanaian football, said he was assassinated.
It has been a cornucopia of women's football for Ghanaians this month, but reactions to the Black Queens' AWCON exit exposed an ugly truth.
Asante Kotoko have been handed a bye to the First Round of the 2018/2019 CAF Confederation Cup after Cameroon failed to nominate a representative.
Hosts Ghana will play no further part in the 2018 AWCON after being held 1-1 by Cameroon in their final Group A game in Accra.
Ghana have been made to wait until their final group game to book their spot in the AWCON semi-final after being defeated 2-1 by Mali in Accra.
Ghana forward Jordan Ayew is confident of coming good at English Premier League side Crystal Palace, after a difficult start to life in London.
Jordan Ayew returned to score twice as Ghana took a step towards the Africa Cup of Nations with a 2-0 win away in Ethiopia.
Ghana coach Bashir Hayford believes his side are ready to end Nigeria's AWCON dominance when the Black Queens host the upcoming biennial showpiece.
Despite the high-profile call-ups to the Ghana fold, it's Thomas Partey who remains the Black Stars' best hope.
Kwesi Appiah has defended his decision to call up some of Ghana's biggest names for the weekend's clash against Ethiopia.
The Internazionale midfielder has pulled out of the Black Stars squad to face Ethiopia this weekend.
Ghana's Black Queens believe the media have a role to play in overcoming the apathy towards women's football that exists in the AWCON host nation.
The Black Stars have revealed that the Internazionale midfielder will not be involved in the Africa Cup of Nations qualifier against Ethiopia.
Kim Grant is confident he can bring the good times back to Accra Hearts of Oak after penning a three-year deal with the Ghanaian giants.
Once Ghana's great hope, the wideman is floundering at Newcastle United ahead of a match against his former club, Bournemouth on Saturday.
Kwesi Appiah's latest Ghana squad has highlighted the severity of one of the Black Stars' longest standing problems.
The Ayew brothers are set to end their year-long absence from the Black Stars squad after being called up for the Ethiopia clash.
Ghana defender Daniel Amartey will be out for four months, Leicester City boss Claude Puel has confirmed.
Former GFA president Kwesi Nyantakyi has indicated he will appeal the lifetime ban imposed on him by FIFA at the Court of Arbitration for Sports.
FIFA have issued a life-time ban from all football-related activity to former Ghana Football Association (GFA) president Kwesi Nyantakyi.