Harry Wilson's excellent free kick in Dublin was the winning goal as Wales beat the Republic of Ireland 1-0 in the UEFA Nations League.
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Aaron Ramsey is likely to leave Arsenal at the end of the season on a free transfer after the club withdrew a contract offer last month.
A dominant Spain made easy work of short-handed Wales on Thursday, rolling to a 4-1 victory in an international friendly.
Bale, who has scored five goals for Real Madrid this season, has been ruled out of the encounter due to muscle fatigue.
The Republic of Ireland will join England, Scotland, Wales and Northern Ireland in exploring a potential bid for the 2030 World Cup.
Ryan Giggs' men came into this on the back of a 4-1 win over Republic of Ireland and, despite starting well, were undone by the Tottenham star.
Wales manager Ryan Giggs enjoyed a memorable first home match in charge as they thrashed Ireland 4-1 in the inaugural UEFA Nations League.
Gareth Bale can handle the pressure of having a more critical role at Real Madrid following the departure Cristiano Ronaldo, says Ryan Giggs.
Wales striker Hal Robson-Kanu has announced his retirement from international football to focus on his club career, the West Brom player said.
Wales manager Ryan Giggs has questioned whether England have the quality in midfield to make a major impact at the World Cup in Russia.
Wales captain Williams said he suffered two broken ribs in a collision with Mexico striker Javier Hernandez which forced him to leave the pitch.
A Mexico team of fringe players never got out of first gear in Monday's draw vs. Wales, but at least El Tri stayed healthy ahead of the World Cup.
A man-of-the-match performance from Wales goalkeeper Wayne Hennessey stopped Mexico from scoring and earned a 0-0 draw in front of 82,345 fans.
Wales manager Ryan Giggs poured praise on Gareth Bale following his match-winning performance for Real Madrid in the 3-1 Champions League victory.
David Brooks insists his future is with Wales and that he will not be returning to the England set-up.
Real Madrid's Gareth Bale and Liverpool's Ben Woodburn were left out for Wales' game vs. Mexico two days after the Champions League final.
Wales will play Spain in a glamour Cardiff friendly in October -- the first fixture between the two countries for 33 years.
Gareth Bale could only leave Real Madrid for another "giant club,'' according to his former boss Chris Coleman.