The United States men's national team will face Paraguay in a friendly in Cary, North Carolina, on March 27.
The game will mark the USMNT's first game at the WakeMed Soccer Park, the 10,000-capacity home of North Carolina FC, since 2006.
The sides have met seven times in the past, with the U.S. winning three while losing two and drawing two. The last meeting came in the 2016 Copa America, when the U.S. won 1-0.
The game falls during an official FIFA international break, so clubs will be obligated to release players ahead of the game.
The federation also confirmed a pair of June friendlies against Republic of Ireland and France, both of which had previously been announced by their opponents.
The U.S. will travel to Dublin to face Ireland on June 2, before a trip to Lyon a week later to face Les Bleus.
The confirmation of the June games also means an end to plans for a mooted tournament featuring other countries who failed to qualify for the World Cup.