Roddick, who lost the 2004 and 2005 Wimbledon finals to Roger Federer, was beaten 6-7 (5), 7-5, 6-4, 7-6 (4) by 40th-ranked Tipsarevic, who has never gone past the fourth round at a major.
"I pretty much choked it," Roddick said. "You want something so bad, you squeeze too tight. I didn't make anything happen tonight. Zero, zero, zero. I played horrific shots on break points. At big moments, I blinked."
The sixth-seeded Roddick went 0-8 on break points, while Tipsarevic converted both of his break chances. Roddick had three set points in the fourth set but couldn't capitalize, and Tipsarevic finished him off in the tiebreak, falling to his hands and knees in celebration on Centre Court.
"Today I could see that he was tight, and this is one of the reasons why, especially in the important moments, I made him play," Tipsarevic said. "I didn't try to hit great shots like impossible, down-the-line shots.
"Professional tennis players feel the intensity and see when the other guy is choking. If you can read that, that's a great benefit for you," he said.
"This means the world to me," Tipsarevic said. "I'm just glad that I won and Serbia will have more representatives in the men's singles draw."
Roddick, 25, won his one and so far only Grand Slam as a
21-year-old at the U.S. Open in 2003.
"By no means am I going to complain about anything that I've
been blessed with, but it's almost at this point win another Slam or what?" Roddick said.
"I want to win another Slam. I could probably coast and not
train and be a top 10 player and kind of have a cushy lifestyle
and be set for as long as I need to be set for. I'm happy as I
can be away from losing tennis matches.
"But I don't I don't know if that appeals to me. I don't
know if I'm satisfied with that. So you do what you can and you
kind of try to put yourself in that position," he said.
Roddick, who split with coach Jimmy Connors in March, won
titles in San Jose and Dubai this year but was sidelined for a
month in the lead-up to Wimbledon with back and shoulder
Indulging in some honest
self-analysis, Roddick used an unusual analogy to assess the current
path of his career.
"You know, when you've seen the Rolling Stones from the
front row, and then all of a sudden you're like seven or eight
rows back and there's a really tall guy in front of you waving
his hands and screaming, you can't see much, it's not going to
be as good as the other show," he said.
"That's kind of what you're going to remember. Maybe you got
to kind of get some baby steps to get back there."
Roddick said after winning the Davis Cup last year as part
of a United States team that it felt on a par with his U.S. Open
triumph but predicted that another Grand Slam triumph could top
"It probably would be better than anything I've felt in
tennis before," he said.
Roddick doesn't see himself being as far away from the top players as he felt in 2006, when he lost in the third round at Wimbledon and fell out of the top 10 for the first time in four years.
"It's not the same as '06 where I couldn't have hit the ball into an ocean from the beach," he said. "I want to win another Slam."
Nadal, who has lost the last two Wimbledon finals to Federer, was broken in the 12th game of the first set Thursday but rallied to dominate the second and fend off the big-serving Latvian in the third-set tiebreak.
He broke in the eighth game of the last set and then held, closing with a forehand winner down the line.
"In the beginning I tried to play aggressive with the second
serve, going inside, but it was impossible. With the first it
was the same, he was serving too good," Nadal said.
"But after going a little bit behind [the baseline] I felt
like I had little bit more control of the situation there."
Four-time French Open champion Nadal is bidding to become only the third man in the Open era after Rod Laver and Bjorn Borg to win both the French and Wimbledon titles in the same year.
After hitting a forehand winner on match point, Nadal let out a shout, dropped into a crouch and pumped his left arm four times -- an unusually ebullient celebration after a second-round match, but indicative of the danger that Gulbis had posed.
"I'm very happy," Nadal said. "I knew I was going to have a very tough match against a very aggressive player. I feel I improved during the match."
In other men's play, 12th-seeded Andy Murray cruised to a straightforward 6-4, 6-2, 6-2 win over Belgium's Xavier Malisse. The match finished with Malisse challenging Murray's 16th ace, which was then confirmed as good by the Hawkeye line-tracking system.
The American No. 9 seed had never progressed beyond the
third round in five previous visits to the All England Club.
Information from The Associated Press and Reuters contributed to this report.