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Serena Williams enters the 2013 US Open as the tournament's top seed with hopes of winning back-to-back titles at Flushing Meadows for the first time in her career. Standing in her way will be a host of talent including last year's runner-up and this year's No. 2 seed, Victoria Azarenka. Who will win the final Grand Slam of the season? Set your rankings!

More: Rank US Open men's contenders

U.S. Open women's contenders

Victoria Azarenka

Victoria Azarenka

WTA ranking: 2
U.S. Open seed: 2

Sara Errani

Sara Errani

WTA ranking: 5
U.S. Open seed: 4

Jelena Jankovic

Jelena Jankovic

WTA ranking: 11
U.S. Open seed: 9

Angelique Kerber

Angelique Kerber

WTA ranking: 10
U.S. Open seed: 8

Petra Kvitova

Petra Kvitova

WTA ranking: 9
U.S. Open seed: 7

Li Na

Li Na

WTA ranking: 6
U.S. Open seed: 5

Agnieszka Radwanska

Agnieszka Radwanska

WTA ranking: 4
U.S. Open seed: 3

Roberta Vinci

Roberta Vinci

WTA ranking: 12
U.S. Open seed: 10

Serena Williams

Serena Williams

WTA ranking: 1
U.S. Open seed: 1

Caroline Wozniacki

Caroline Wozniacki

WTA ranking: 8
U.S. Open seed: 6

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Andy Murray, the second-ranked men's tennis player, was recently challenged by a fan on Twitter to play Serena Williams. Murray responded in a column for BBC Sport saying he would be up for it and that it could be good for the game. The scenario was then presented to Williams whose response you can see in the video above. Tennis fans immediately responded with a flood of comments about what would happen if the two faced off on the court. Cast your vote and join the conversation.

What do you think? Leave your comments below.

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