But which Monday night games are generating the most excitement in SportsNation? The first MNF game of the season will feature Tom Brady's return to football, which happens to coincide with Terrell Owens' Bills debut. Which player will deliver the better performance?
Below, we've listed what we think will be some of the season's best games, and now it's up to you to pick which matchups you find most appealing. Cast your vote, then see how the rest of the country voted!
More: Best Week 1 games