San Francisco 49ers at New York Jets
Alex Smith and Mark Sanchez have both received their share of criticism, but both have their teams in good positions.
Vote: Five questions for 49ers at Jets
New York Giants at Philadelphia Eagles
The Eagles have had heaps of trouble with turnovers this year, never a good problem area to have against the Giants.
Vote: Five questions for Giants at Eagles
Carolina Panthers at Atlanta Falcons
The Panthers were supposed to be a darkhorse team this season, but a series of gaffes have left them reeling.
Vote: Five questions for Panthers at Falcons
New England Patriots at Buffalo Bills
The Patriots' defense has improved, but that wasn't difficult to do after last year's debacle.
Vote: Five questions for Patriots at Bills
Green Bay Packers at New Orleans Saints
Both the Saints and Packers have won recent Super Bowls, but they've only one win between them this year.
Vote: Five questions for Packers at Saints
Week 4 NFL Pick 'Em
Do you see any upsets brewing among the big games this week?
Vote: Pick the winners in every Week 4 game