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Nick Kyrgios ends Novak Djokovic's 19-match win streak at Indian Wells

INDIAN WELLS, Calif. -- Novak Djokovic's 19-match win streak at the BNP Paribas Open ended in a 6-4, 7-6 (3) fourth-round upset loss to No. 15 seed Nick Kyrgios on Wednesday.

It was Kyrgios' second win over the world's second-ranked player in two weeks. He also beat Djokovic in straight sets at Acapulco on March 2.

"That felt good to kind of prove it wasn't a one-off thing," Kyrgios said. "I competed for every point. It was hot out there. We played for two hours. It was just a good, honest win."

Djokovic was bidding for a fourth consecutive title at Indian Wells, having won a total of five in his career. But he unraveled with 25 unforced errors, including a forehand service return on Kyrgios' second match point.

"Conditions like today, where the ball travels through the air very fast and it bounces very high, it's a gamble,'' Djokovic said. "On his first serves, to try to anticipate and read his serve, where he's going to go 140 miles per hour down the T and also pretty good angle wide, it's hard to position yourself well.''

Kyrgios hit 14 aces, with his fastest serve clocking 141 mph, and won 86 percent of his first-serve points. He advances to the quarterfinals, in which he will face Roger Federer, who easily dispatched longtime rival Rafael Nadal 6-2, 6-3 in 68 minutes on Wednesday night.

Stan Wawrinka, virtually the forgotten man despite being seeded third, pulled off a 3-6, 6-3, 7-6 (4) victory over lucky loser Yoshihito Nishioka, who twice served for the match.

Also advancing to the quarterfinals were No. 4 seed Kei Nishikori, who defeated Donald Young 6-2, 6-4; 17th-seeded Jack Sock, a 4-6, 7-6 (1), 7-5 winner over Malek Jaziri; No. 21 Pablo Carreno Busta, who beat qualifier Dusan Lajovic; and No. 27 Pablo Cuevas, who outlasted 11th-seeded David Goffin 6-3, 3-6, 6-3.

On the women's side, No. 3 Karolina Pliskova got by seventh-seeded Garbine Muguruza 7-6 (2), 7-6 (5) and next faces No. 8 Svetlana Kuznetsova, who beat 19th-seeded Anastasia Pavlyuchenkova 6-3, 6-2 to reach the semifinals.

The Associated Press contributed to this report.