ROME -- Novak Djokovic overcame a challenging first set to beat British qualifier Aljaz Bedene 7-6 (2), 6-2 in his opening match at the Italian Open on Tuesday.
Bedene frustrated Djokovic for long stretches with his foot speed, keeping the ball in play and whipping surprising winners.
At the conclusion of a tight first set, Djokovic served three aces in the tiebreaker then laughed to himself in apparent astonishment. He had an easier time in the second set to advance in Rome.
Defending champion Andy Murray, meanwhile, was eliminated by local favorite Fabio Fognini 6-2, 6-4 before a raucous crowd.
Also, David Goffin rallied past Fernando Verdasco 3-6, 6-3, 6-2; Tomas Berdych notched his 600th career win by beating qualifier Carlos Berlocq 6-3, 6-4; Jack Sock defeated Diego Schwartzman 6-4, 1-6, 7-5; and Alexander Zverev outlasted Kevin Anderson 6-4, 4-6, 6-4.
Nick Kyrgios withdrew from the tournament with a hip injury.
In other women's action, last year's finalist, Madison Keys, was beaten by Australian qualifier Daria Gavrilova 2-6, 7-5, 7-5.
Keys is still struggling to regain her form after left wrist surgery in the offseason. She also had opening-round losses in her previous two tournaments in Charleston and Madrid.
The 33rd-ranked Gavrilova had to come through qualifying because she forgot to enter the main draw.
Also, fifth-seeded Johanna Konta defeated Yulia Putintseva 6-3, 6-0; Ekaterina Makarova eliminated Roberta Vinci 6-2, 6-1; and qualifier Catherine Bellis beat Misako Doi 6-4, 7-6 (6).
The Associated Press contributed to this report.