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American John Isner notches 22 aces in first-round win at US Open

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Isner trying not to look too far ahead at US Open (4:32)

No. 10 seed John Isner sits down with ESPN's team of analysts to discuss his first-round victory and his favorable US Open draw. (4:32)

John Isner, the highest-ranked American man, delivered 22 aces and was broken only once in a 6-1, 6-3, 4-6, 6-3 victory over Pierre-Hugues Herbert of France in the US Open's first round.

The 10th-seeded Isner converted 5 of 9 break points while saving 6 of the 7 he faced.

In addition to Isner, Americans Sam Querrey and Steve Johnson also advanced Monday. Unlike his countrymen, Jack Sock was ousted in the first round, falling 6-2, 7-6 (12), 1-6, 5-7, 6-4 to Australian Jordan Thompson.

Isner next faces Hyeon Chung of South Korea. Johnson plays Kyle Edmund of Britain in the second round.

Also on Monday: Marin Cilic, the 2014 US Open champion, made it through his opening-round match against aptly named American Tennys Sandgren with a 6-4, 6-3, 3-6, 6-3 victory.

The fifth-seeded Cilic was playing his first match since losing to Roger Federer in the Wimbledon final last month. No man has ever won the US Open after not entering any tournaments between the All England Club and Flushing Meadows.

Cilic didn't even practice for two weeks because of a left leg injury. But he produced 55 winners Monday, 33 more than Sandgren.

The 105th-ranked Sandgren, whose name comes from his Swedish great-grandfather and has nothing to do with tennis, pumped his fist after he held serve to win the third set.

Cilic next faces Florian Mayer, who won 7-5, 0-6, 6-3, 6-4 over Rogerio Dutra Silva.

David Ferrer, the 2013 French Open runner-up, fell to 103rd-ranked qualifier Mikhail Kukushkin of Kazakhstan 4-6, 6-3, 6-2, 6-1.

Ferrer made a surprise run to the semifinals of the hard-court Cincinnati Masters earlier this month.

In other matches, 12th-seeded Pablo Carreno Busta defeated American Evan King 6-3, 6-2, 7-6 (5); Edmund of Great Britain defeated No. 32 Robin Haase of the Netherlands 6-3, 7-5, 6-3; and British qualifier Cameron Norrie defeated Russian Dmitry Tursunov, who retired after dropping the first two sets 7-6 (7), 6-1.

No. 23-seeded Mischa Zverev came back from a set down to beat NCAA champion Thai-Son Kwiatkowski 7-6 (5), 4-6, 4-6, 7-5, 6-3 in a 3½-hour battle.

Zverev, who upset Andy Murray on his way to a quarterfinal run at this year's Australian Open, got all he could handle from the 710th-ranked Virginia Cavalier, whose collegiate title in May earned him a wild card into the US Open main draw.

Zverev will next face Frenchman Benoit Paire, a 6-3, 6-2, 7-6 (5) winner over Lukas Lacko.

Also advancing Monday was Denis Shapovalov, who put away Russia's Daniil Medvedev, 7-5, 6-1, 6-2. The 18-year-old Canadian became the youngest player to reach the semifinals of an ATP Masters 1000 event at the Rogers Cup in Montreal earlier this month, but had to qualify to get into the US Open main draw. The 69th-ranked Shapovalov will meet eighth-seeded Frenchman Jo-Wilfried Tsonga, a 6-3, 6-3, 6-4 winner over Marius Copil of Romania.

Thomas Fabbiano of Italy was also a four-set winner over Australian qualifier John-Patrick Smith. Next up for Fabbiano is another Australian in Thompson, who needed five sets to put away Sock.

Information from The Associated Press was used in this report.