MASON, Ohio -- Andy Murray's off-day turned into the biggest upset of the Western & Southern Open on Thursday, a straight-set loss that left him with little hard-court experience heading into the U.S. Open.
Murray lost 6-4, 6-4 to France's Jeremy Chardy, an opponent he'd beaten easily the four previous times they'd played. Chardy reached the quarterfinals with steady play, while Murray had trouble controlling his shots on a hot and breezy afternoon.
"I was a little bit uncomfortable with those balls bouncing extremely high," said Murray, who left the court as soon as the match ended and headed directly to the interview room. "It was fairly hard to control."
Top-ranked Roger Federer reached the quarterfinals with his second quick match in two days. Mardy Fish and Juan Martin del Potro also reached the quarterfinals on Thursday. Novak Djokovic advanced in the evening when Russia's Nikolay Davydenko had to quit after one set.
She returned to Wimbledon and won the gold medal in singles and in doubles with sister Venus. On Thursday, she felt a little drained in the 85-degree heat.
"I have been playing a lot," she said. "Definitely (need) more energy. Been traveling a lot, been training a lot. You know, it's been a really big summer."
Later, Venus Williams needed a long break between sets before pulling off a 6-3, 6-0 win over Italy's Sara Errani.
Murray also won the gold medal at Wimbledon, the highlight of his career. He went to Toronto last week hoping to get in shape for the hard-court season, but had to withdraw because his left knee started hurting in the transition from grass.
He felt good and moved well in an opening two-set win on center court Wednesday. Playing on the grandstand court a day later, he never got into a rhythm with his shots and repeatedly wasted chances to break Chardy, who had won only one set against him in their four previous matches.
Now, Murray heads to New York to practice for the U.S. Open, having played only three matches on hard courts since returning from Wimbledon's grass.
"I won't play any more matches," Murray said. "When going into the big tournaments, sometimes I've won tournaments in the buildup and it hasn't helped me. This year at Wimbledon, I lost in the first round at Queen's and made the final there for the first time. I have won Queen's before and not done well at Wimbledon.
"So it doesn't normally have that much bearing. But obviously I would have liked to have done a bit better this week."
Federer beat Bernard Tomic 6-2, 6-4 and has looked sharp in his two hard-court matches since losing to Murray in the gold-medal match. Federer skipped the Rogers Cup last week.
"I feel like things are working really well for me," Federer said. "Regardless of what's going to happen, I'm feeling good, I'm healthy, I have no issues. I'm happy I got over the jet lag, and so the risk is less to get injured and all those things. So I'm in a good place right now."
Djokovic was on the court for only 30 minutes in the evening. Russia's Davydenko quit after losing the first set 6-0, bothered by a sore right shoulder. He called the trainer over at the break, then decided not to continue.
Davydenko warmed up fine, but his serve quickly deteriorated. He had eight double faults, made 16 unforced errors and won only 16 points.
"You definitely don't want to win like this," Djokovic said. "Obviously he couldn't serve over 90 mph (by the end of the set) and he had a lot of double faults. Something was bothering his shoulder. Hopefully he'll be able to recover in time for the U.S. Open."
Fish, a two-time runner-up at the tournament in suburban Cincinnati, beat Radek Stepanek 6-3, 6-3, his first win over the Czech in five career matches. Fish celebrated his win with a leaping right fist pump after Stepanek's backhanded drop shot hit the net on match point.
"That was the monkey jumping off my back," Fish said. "He's been a tough opponent for me. Not only has he beaten me, but he's beaten me soundly."
Fish said the difference this time was his physical condition. He continues to improve after undergoing surgery in May to repair a heart condition.
"I feel fresher, stronger," he said. "The summer's gone well for me as far as getting my match fitness back."
The American hasn't dropped a set and has been broken only once while reaching the quarterfinals.
Serbia's Viktor Troicki took del Potro to three sets before fading. The Argentinian improved to 6-0 career against Troicki with a 7-6 (2), 2-6, 6-1 win.
On the women's side, top-seeded Agnieszka Radwanska overcame an unexpected challenge from wild-card Sloane Stephens before winning 6-1, 4-6, 6-4. Radwanska, who lost to Serena Williams in the Wimbledon final, reached the tournament's quarterfinal for the first time in three appearances.
Like Murray, she had trouble with the condition on the grandstand court.
"It was so hot and windy," she said. "I think that this court was slower than the center (court) and the ball didn't go at all. I was hitting as much as I could, but it just was hard to make winners there."
Rain forced suspension of sixth-seeded Caroline Wozniacki's match -- she trailed Anastasia Pavlyuchenkova 6-4 after one set -- and postponement of ninth-seeded Li Na's match against Johanna Larsson. They will play at 11 a.m. on Friday, with the winners having to play evening quarterfinal matches.
Information from The Associated Press was used in this report.