WINSTON-SALEM, N.C. -- A highly seeded player and another well-known one are headed home early from the Winston-Salem Open.
Seppi, who was No. 23 in the ATP world rankings, was beaten by American qualifier Steve Johnson 6-7 (5), 6-4, 7-5.
Fish retired in the third set of his match with Jarkko Nieminen. The No. 11 seed from Finland was leading Fish 7-5, 6-7 (3), 3-2.
Fish said in a statement issued by the ATP he developed "heat stroke" and the "very hot and humid" weather made it difficult to continue the match.
"The weather just got to me a little bit and I just couldn't go any more," Fish said.
The tournament lost two of its top three seeds Monday when top-seeded Tomas Berdych and third-seeded John Isner, the two-time defending champion, withdrew with injuries. Those two met in last year's final.
Fourth-seeded Tommy Robredo of Spain is the last of the top four seeds remaining.
Robredo, at No. 22 in the ATP rankings, beat France's Guillaume Rufin 7-6 (5), 4-6, 6-3 in the final match of the night.
In other second-round matches, fifth-seeded Benoit Paire of France beat American James Blake 7-6 (9), 2-6, 6-3; seventh-seeded Fernando Verdasco of Germany beat American Tim Symczek 3-6, 6-3, 6-3; ninth-seeded Jurgen Melzer of Austria beat qualifier Thiemo de Bakker 7-5, 6-7 (4), 4-2; and 13th-seeded Dmitry Tursunov of Russia defeated qualifier David Goffin of Germany 4-6, 7-5, 6-1.