The school announced Stafford-Odom's hiring Monday.
Stafford-Odom spent the past three seasons at Division II Concordia Irvine in California. She spent two years each on the staffs at North Carolina and Duke before that and has also been an assistant at UCLA.
Athletic director Ingrid Wicker McCree said Stafford-Odom "will definitely help move our women's basketball program to the next level."
Stafford-Odom replaces Vanessa Taylor. McCree said in March that Taylor's contract would not be renewed after she went 33-113 in five seasons and 8-21 in 2016-17.