South Carolina coach Dawn Staley said Wilson sprained her ankle after stepping on someone's foot and would probably need a day off from practice to get ready to face No. 6 Tennessee on Sunday.
"We'll see how it is," Staley said. "She could probably take a day off and still play."
Wilson came down hard under her own basket with 16 seconds left in the game and hobbled over to the corner of the court. Team trainers helped her off and she went right to the locker room.
Worried that her senior season might be hampered by injury? No, said teammate Tyasha Harris.
"She was the same happy-go-lucky," Harris said, smiling. "That's how she is."
Wilson recorded her 12th double-double this season and, in the first quarter, became just the third player in program history to reach 2,000 career points.
Information from The Associated Press was used in this report.