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Expert picks: Predicting the Elite Eight

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Challenges ahead for Mississippi State's defense (1:58)

Andy Landers and Nell Fortner focus on Mississippi State's defense and the problems UCLA guard Jordin Canada could present for the Bulldogs. (1:58)

Just three years ago, all four No. 1 seeds reached the Final Four. Will chalk hold all the way to Columbus, or will there be upsets in the Elite Eight? Oregon, not defending-champion South Carolina, might be the No. 2 seed that shakes things up.