Rapid Reaction: Giants 27, Bills 24

EAST RUTHERFORD, N.J. -- Here are some thoughts on the New York Giants' 27-24 victory over the Buffalo Bills:

What it means: The Bills lost for the second time in three weeks and fell to 4-2. Buffalo has been in first place in the AFC East for several weeks but runs the risk of losing that spot to the New England Patriots (4-1), who play the Dallas Cowboys later on Sunday. Buffalo also has yet to pick up a quality road win this season.

Shaky defense: Buffalo’s defense continues to struggle and give up chunks of yards. The Bills allowed 414 yards of total offense against New York. Bills cornerback Drayton Florence had his worst game of the season. He allowed a 60-yard catch to receiver Hakeem Nicks that set up one New York touchdown before halftime. Florence also had a key pass interference call against Nicks late in the fourth quarter to set up the Giants’ winning field goal.

Big-play offense: Fred Jackson’s 80-yard touchdown run was one of the best offensive plays you will see all season. Buffalo executed the play perfectly in the first quarter, and Jackson went virtually untouched for the score. Jackson showed his deep speed by running past New York defenders and not getting caught from behind. On Buffalo’s next drive, receiver Naaman Roosevelt caught a 60-yard touchdown reception to give the Bills their first lead of the game, 14-7, at the end of the first quarter. Eventually, some costly turnovers hurt Buffalo.

Injury watch: The Bills suffered another big injury on the offensive line. Starting tackle Chris Hairston suffered an ankle injury in the fourth quarter that knocked him out the game. He had trouble putting weight on the ankle. Buffalo also played without defensive players Shawne Merriman (Achilles) and Kyle Williams (foot).

What’s next: This Bills will take their 4-2 record into the bye week. Buffalo will continue its tour of the NFC East with its next game against the Washington Redskins on Oct. 30.