Can Fred Jackson save the day?

The Buffalo Bills are expected to enter their biggest game to date Sunday against the New England Patriots without leading rusher C.J. Spiller.

But can former starting running back Fred Jackson save the Bills?

This would be a good example of musical chairs if Jackson can pull it off. He suffered a knee injury in Week 1 against the New York Jets and Spiller took over. Now, Spiller has a shoulder injury and Jackson is healing faster than expected. Jackson says he's about 70-75 percent sure he can play against the Patriots.

Sunday's game at Ralph Wilson Stadium will have huge AFC East implications. The Bills (2-1) have a chance not only to improve to 3-1 but also put the Patriots in a 1-3 hole. A loss would put both teams even at .500.

If Jackson can get healthy and quickly return to his 2011 form, the Bills have a chance to beat New England at home for the second straight year.