Wrap-up: 49ers 45, Bills 3

Here are some thoughts on the San Francisco 49ers' 45-3 victory over the Buffalo Bills.

What it means: It means the Bills lost their second game in a row in blowout fashion. Buffalo, which is 2-3, has been outscored 97-31 the past two games. The Bills have some talent, but they are proving they're not even close to competing with the top teams in the NFL. Bills head coach Chan Gailey questioned his team's toughness during the week -- and it's a legitimate concern. There is no excuse for Buffalo to lose by an average of 33 points the past two weeks.

What I liked: There's not much to like in this blowout. Backup cornerback Leodis McKelvin did a good job in the return game. He took a kickoff for 59 yards and a punt return for 28 yards. Other than that, there weren't many Bills highlights in this blowout loss.

What I didn't like: The Bills left their offense in Buffalo. The group that came out West could not execute or do anything with consistency. Bills tailbacks C.J. Spiller and Fred Jackson didn't make an impact against San Francisco. Buffalo quarterback Ryan Fitzpatrick also had trouble with his accuracy and threw an interception. Buffalo tight end Scott Chandler had a big fumble late in the first half that the 49ers turned into a touchdown and a 17-3 lead. The Bills were never able to recover from that deficit. Buffalo’s defense also was disappointing. The 49ers averaged 8.2 yards per carry and allowed Alex Smith to throw for 303 yards and three touchdowns.

What's next: The Bills will be on the road again next week to face another NFC West team. Buffalo will travel to play the Arizona Cardinals (3-1), who will have 10 days to prepare for this game. The Bills have playoff expectations and need to stop their season from going downhill. Buffalo must respond now or it could be a long, disappointing season.