In fact, 32 of the team's 44 points -- a preseason franchise record -- were scored by rookies.
Here's a look at how Buffalo's draft choices, plus some undrafted free agents, performed:
Quarterback EJ Manuel (first round) -- Started and played the full first half, going 16-of-21 passing for 107 yards, one touchdown, and no interceptions. Was credited with a fumble on a botched handoff in the first quarter.
Wide receiver Robert Woods (second round) -- Started and was targeted five times, all in the first half. Finished with four receptions for 32 yards, but muffed a punt return on the opening drive.
Wide receiver Marquise Goodwin (third round) -- Returned the Colts' first kickoff 53 yards in the first quarter, then took another kick 107 yards for a touchdown in the second quarter. Was flagged for unnecessary roughness on Woods' muffed punt on the opening possession.
Safety Duke Williams (fourth round) -- Had three tackles in his preseason debut.
Safety Jonathan Meeks (fifth round) -- Had one tackle and one pass defensed, but was unable to corral a would-be interception.
Kicker Dustin Hopkins (sixth round) -- Was 2-for-2 on field goals, but had a kickoff in the second quarter go out of bounds, setting the Colts up from their own 40-yard line.
Tight end Chris Gragg (seventh round) -- Was targeted four times, making two catches for 12 yards.
Quarterback Jeff Tuel (undrafted) -- Played the entire second half, completing 19 of 23 passes for 212 yards, two touchdowns, and no interceptions. Had a strip-sack fumble early in the fourth quarter that was returned by the Colts 72 yards for a touchdown.
Wide receiver Brandon Kaufman (undrafted) -- Lanky receiver had a 29-yard catch on the final play of the third quarter, and added a 5-yard touchdown grab late in the fourth quarter.
Wide receiver Da'Rick Rogers (undrafted) -- Was targeted just once in the game, but his 6-yard touchdown reception capped an 80-yard drive to begin the third quarter.
Cornerback Jumal Rolle (undrafted) -- A Division II prospect from Catawba College, Rolle returned an interception 17 yards for a touchdown in the fourth quarter.