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Mike Gillislee would lead Bills' backfield without LeSean McCoy

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McCoy's hamstring could keep him out for a few weeks (0:38)

Josina Anderson says that based on LeSean McCoy's history of hamstring injuries, the Bills may decide to hold him out until he is completely healthy. (0:38)

ORCHARD PARK, N.Y. -- LeSean McCoy has been playing this season at a level that should put him in consideration for NFL MVP, so naturally him being limited in Wednesday's practice with a hamstring injury creates some concern around a team that is riding a four-game winning streak.

It's not yet known whether McCoy will be able to play Sunday against the Miami Dolphins. If he is sidelined, his top backup Mike Gillislee will likely receive the start, but that doesn't mean Gillislee will necessarily fill McCoy's entire role in the offense.

"In my opinion, he's one of the best players in the league. We're a lot better with him than we are without him," center Eric Wood said Wednesday. "Not one person replaces him. The whole running back group would then have to step up.

"I have faith that people will step up, just like when Sammy [Watkins] went down [in Week 3], it gave guys an opportunity, and people stepped up and made plays around him."

Gillislee has taken 17 carries this season for 117 yards and two touchdowns, while he's added three catches for 27 yards and one touchdown. Beyond Gillislee, who has been on the field for 68 snaps this season, the impact of the Bills' other running backs has been minimal. Rookie Jonathan Williams has taken 14 snaps, while August free-agent signing Reggie Bush has been limited to a surprisingly-low 11 snaps.

"I feel great. I haven't had much work, so I'm definitely healthy," Bush said with a chuckle Wednesday.

If McCoy can't play Sunday, one option is for the Bills to lean more on their passing game more than they have over their past four games. 57.6 percent of the Bills' total offensive yards have been through rushing during their winning streak, which is by far the highest percentage in the NFL and significantly higher than the league average of 30.6 percent.

However, the Bills' top passing weapons are banged up. Watkins remains on injured reserve with a foot injury and isn't eligible to return until Nov. 27. Tight end Charles Clay missed Wednesday's practice with an ankle injury, while receiver Robert Woods was in a walking boot Wednesday because of a foot injury that kept him out of practice.

Rex Ryan is hopeful that both Clay and Woods will be able to play Sunday.

"I feel pretty good that hopefully our guys will play," Ryan said Wednesday. "I don’t think I’m overly concerned with anybody, but with that being said, anytime you’re not able to practice, there may be some concern there."

Wood doesn't expect the offense to change its approach despite the injuries.

"I'd imagine the game plan will stay pretty similar," Wood said. "It'll just be different faces in those roles, and we'll see how it goes."