The regular season kicks off with the Houston Texans visiting the Kansas City Chiefs on Thursday, Sept. 10 (8:20 p.m. ET, NBC). The opening doubleheader for Monday Night Football will feature the Pittsburgh Steelers at the New York Giants (7:10 p.m. ET, ESPN) and the Tennessee Titans at the Denver Broncos (10:20 p.m. ET) on Monday, Sept. 14.
Check out the full week-by-week schedule here. Here's what is in store for the Bills:
Bills reporter Marcel Louis-Jacques is predicting a 12-4 finish:
Sept. 13: vs. N.Y. Jets, Win
Sept. 20: at Miami, Win
Sept. 27: vs. LA Rams, Win
Oct. 4: at Las Vegas, Win
Oct. 11: at Tennessee, Loss
Oct. 15: vs. Kansas City, Loss
Oct. 25: at N.Y. Jets, Win
Nov. 1: vs. New England, Win
Nov. 8: vs. Seattle, Loss
Nov. 15: at Arizona, Win
Nov. 22: BYE
Nov. 29: vs. L.A. Chargers, Win
Dec. 7: at San Francisco, Loss
Dec. 13: vs. Pittsburgh, Win
Dec. 20: at Denver, Win
Dec. 28: at New England, Win
Jan. 3: vs. Miami, Win
Strength of schedule: T-5th, .525
Bills fans clamored all offseason for their team to get more nationally televised games -- and the NFL granted their wish. Buffalo will play four prime-time games this season, including a Thursday night showdown with the Chiefs, Monday Night Football matchups with the 49ers and Patriots, and a Sunday night game against the Steelers. If the Bills make the postseason for the third time in four years, the rest of the country should be plenty familiar with them.
With four winnable games in its first four weeks, Buffalo needs to start the season strong because the schedule gets dicey from Week 5 through Week 14 -- a stretch that includes games against the Titans and Chiefs in consecutive weeks, the Seahawks, Cardinals, 49ers and Steelers. There are games against the Jets, Patriots and Chargers sprinkled in that stretch -- it's a period of the season that could heavily affect the Bills' playoff chances. At the same time, it will ensure the team is battle-tested by the time January comes about.
The farthest west the Bills traveled last season was their postseason game in Houston. This season, they will travel to San Francisco, Phoenix, Denver and Las Vegas. There will be little time to rest, as well -- Buffalo has one set of back-to-back home games, although it will get four home games and a bye week between Week 6 and Week 12. The Bills were dynamite on the road last season, losing twice in eight tries; if they're able to replicate that in 2020, it will almost certainly mean another trip to the playoffs.