Can the Titans overcome a lack of practice against the red-hot Bills?

Bills (4-0) at Titans (3-0)

Tuesday, 6 p.m. ET | CBS

Matchup rating: 62.2 | Spread: BUF -8.5 (NA)

What to watch for: The Titans are without several key players, including Adam Humphries, Jeffery Simmons and Corey Davis, who have been placed on the Reserve-COVID list, and the team hasn't practiced or been in its facility to prepare for this game. Keep an eye on how they start the game after having so much time off. If Tennessee gets off to a slow start, this could get ugly quickly. -- Turron Davenport

Bold prediction: The Bills finally get loose in the run game for at least 150 yards. They rank 28th in the league in rushing yards per game, but the Titans rank 29th in rushing yards allowed. It's a true matchup of a stoppable force meeting a movable object. But Buffalo's ranking seems more like an outlier, given its top-10 finish last season and improved backfield. -- Marcel Louis-Jacques

Stat to know: Tennessee quarterback Ryan Tannehill is averaging 11.2 yards per attempt with play-action (fourth) but just 5.9 per attempt without play-action (28th).

Injuries: Bills | Titans

What to know for fantasy: Last week, Buffalo quarterback Josh Allen tied the longest streak in Bills history with his fourth straight game of 280 passing yards and multiple touchdown passes. The only other instance of that for the Bills was Drew Bledsoe in 2002. See Week 5 rankings.

Betting nugget: Tennessee is the third team in Super Bowl era to start 3-0 straight up and 0-3 against the spread (ATS). Read more.

Louis-Jacques' pick: Bills 38, Titans 24

Davenport's pick: Bills 35, Titans 21

FPI prediction: BUF, 52.4% (by an average of 0.9 points)

Matchup must-reads: Bills' Allen evoking MVP seasons by Mahomes, Jackson ... Source: Titans informed of rules prior to players' informal workouts ... Norman brings 'a lot of energy,' a forced fumble in Bills debut ... Timeline of the NFL COVID-19 outbreak: How positive tests led to postponed games