4:25 p.m. ET | CBS
Matchup rating: 25.3 | Spread: LAC -7.5 (49)
What to watch for: It's Justin Herbert vs. Gardner Minshew -- if Minshew plays, that is. He might be benched in favor of Mike Glennon. Herbert recalled facing Minshew in college, when he was at Oregon and Minshew was under center for Washington State. It's an interesting battle of young QBs. Per research by the Elias Sports Bureau, Herbert needs 285 passing yards to have the fifth most in a player's first five career games. And Minshew is coming off five consecutive games with 40-plus pass attempts, the longest streak in Jaguars history. -- Shelley Smith
Bold prediction: The Jaguars will tie an NFL record by allowing the Chargers to score 30-plus points. That would mark the sixth consecutive game in a single season in which they've allowed 30 points. The Chargers have scored 58 points in their past two games, and as Herbert gets more comfortable, he'll thrive against a Jaguars defense that struggles to rush the passer. -- Mike DiRocco
Stat to know: Jacksonville running back James Robinson has 569 yards and four touchdowns from scrimmage this season, both second among rookies (TDs is tied for second).
What to know for fantasy: Dak Prescott was the only quarterback to outscore Herbert in Weeks 4-5 (the Chargers were on bye last weekend). See Week 7 rankings.
Betting nugget: Anthony Lynn is 5-14-1 ATS as a home favorite since becoming the Chargers' coach in 2017. Read more.
DiRocco's pick: Chargers 35, Jaguars 18
Smith's pick: Chargers 27, Jaguars 14
FPI prediction: LAC, 71.7% (by an average of 7.8 points)
Matchup must-reads: Jaguars' Marrone won't rule out sitting Minshew ... Young Chargers hope bye week helps them blast off under Herbert ... Marrone: No plans to fire DC Wash ... Bye week shift might be a (rare) good break for the Chargers ... Aaron Lynch ending retirement to join Jaguars