SAN DIEGO -- It’s pretty unusual to make a game-changing play for one team, and then line up against them the following week.

But new San Diego Chargers defensive end Lawrence Guy could get that opportunity on Monday, when the Indianapolis Colts come to town.

Guy blocked a field goal attempt by Seattle kicker Steven Hauschka that was returned 61 yards by Delano Howell in the Colts’ 34-28 win over the Seahawks last Sunday. Guy played 23 snaps on defense and another 16 on special teams.

A day later the Colts waived Guy to make room on the 53-man roster for receiver LaVon Brazill, who was suspended for the first four games for violating the NFL’s substance abuse policy.

Guy hopes he’s active on Monday night so he can play against his former teammates.

“I can’t wait,” Guy said. “I spent almost a year and a half playing against those guys in practice, so if they activate me, it’s going to be fun going against those familiar faces again.”

A Las Vegas native who played at Arizona State, Guy said he’s pleased to be back on the West Coast where most of his family is located. And he should not face a big adjustment in terms of scheme, with the Colts and Chargers both running a 3-4 defensive alignment.

At 6-foot-4 and 318 pounds, Guy will be asked to give San Diego depth at defensive end.

While there are little secrets between teams in the league, with Guy, recent practice squad addition running back Kerwynn Williams and general manager Tom Telesco all having ties to the Colts, San Diego coach Mike McCoy should have a good idea of Indianapolis’ scheme, personnel and tendencies in game-day situations.

“We’re trying to do what’s best for the football team,” McCoy said. “And we’re trying to get players that can help us win, and that’s what we’re looking to do every week, week in and week out. It just happened that we’re playing them this week.

“So we made some changes on the roster, obviously. They came from Indy, so we’ll ask them a few questions.”