Palmer is again questionable as the Cardinals visit the New York Giants on Sunday at MetLife Stadium. The quarterback has been limited all week in practice with a sore right shoulder that Arizona coach Bruce Arians called a "nerve thing."
"They're very finicky" he said.
Palmer went 3-0 when he was questionable last season. If Palmer can't play Sunday, Drew Stanton would get his first start -- and playing time -- since Dec. 19, 2010, a stretch of three years, eight months and 26 days.
"We've been down this road before," Arians said. "I think the best game he had last year he didn't practice at all [before]. Sometimes at his age it's good not to throw it."
Against St. Louis in Week 13 last season, Palmer, who didn't throw during the week leading up to the game, went 27-for-32 passing, or an 84.4 percent completion rate.
Sunday may also bring the 2014 debut of safety Tyrann Mathieu, who was listed as probable. Mathieu hasn't played since Week 13 of last season when he tore his ACL and LCL.
Running back Andre Ellington is expected to play after missing practice Wednesday and Thursday, and being limited Friday. He was listed as questionable. Ellington will likely be limited in practice next week as he continues to recover from a left foot injury.
As expected, linebacker Alex Okafor (thigh) and defensive tackle Frostee Rucker (calf) were ruled out of the game. Punter Dave Zastudil (groin) was labeled questionable although it's likely he'll continue holding for rookie kicker Chandler Catanzaro.