8:15 p.m. ET | ESPN
Matchup rating: 94.7 | Spread: BAL -3.5 (53.5)
What to watch for: Can the Ravens jump out to another early lead? Since Lamar Jackson took over as Baltimore's starter midway through the 2018 season, the Ravens are an NFL-best 19-0 when leading at halftime and 0-5 (including the playoffs) when trailing after two quarters. The Ravens haven't trailed at any point in the second half in their last 12 games, which is the third-best streak in league history. -- Jamison Hensley
Bold prediction: The Chiefs and Ravens will combine for 900-plus yards and at least 60 points. Both teams are in the top 10 in points allowed, but don't look for a defensive battle. This game will be similar to the one from Week 3 last season, when the meeting produced 955 yards and 61 points. -- Adam Teicher
Stat to know: The Ravens have won 14 straight regular-season games, and the Chiefs have won eight straight -- the two longest active win streaks in the NFL. The last time two teams met on 8-plus-game win streaks was 1969, when the Rams (11 straight) hosted the Vikings (10 straight). This also marks the fifth QB matchup between the reigning MVP (Jackson) and Super Bowl MVP (Patrick Mahomes). The Super Bowl MVP won the previous four matchups.
What to know for fantasy: The quarterbacks will get the headlines, but when these two teams met in Week 3 last season, there were three running backs who reached double-figure point totals. See Week 3 rankings.
Betting nugget: In the last 20 seasons, reigning Super Bowl champions are 11-1 ATS as underdogs within the first three weeks of the season. And Mahomes is 10-2 ATS in September games with 28 passing TDs and zero interceptions. Read more.
Teicher's pick: Ravens 34, Chiefs 31
Hensley's pick: Ravens 31, Chiefs 30
FPI prediction: BAL, 59.6% (by an average of 3.4 points)
Matchup must-reads: Ravens' Jackson downplays matchup vs. Chiefs ... Why Mahomes makes his home in KC, not NYC ... Former Ravens OL Urschel left NFL for MIT ... Chiefs' Watkins placed in concussion protocol ... Ravens karate kick away doubts they can't win without Lamar ... Best regular-season game in Baltimore? ... Mahomes can 'make stuff happen' with his feet