BOSTON -- As usual, the Chicago White Sox were upstaged by their North Side neighbors, the Cubs, whose visit here last month was given the Full Monty in terms of publicity, the Cubs not having been seen in these parts since 1918.

But in terms of creating a public nuisance, it was no contest. Ozzie Guillen and his White Sox may be second-class citizens in their own town, but against the Red Sox, they have the run of the place. In what has become an unsettling trend for the Red Sox in recent years, the White Sox completed a three-game sweep here with a 7-4 win, a victory that was all but assured when Paul Konerko hit a two-run home run off Jonathan Papelbon in the ninth inning.

The Red Sox have now lost six straight to the White Sox, matching their longest losing streak against the South Siders in 45 years (Aug. 28, 1965-May 30, 1966). They've also lost 10 of 11 and 13 of 15 against Chicago since Aug. 27, 2009, even though the White Sox haven't exactly ranked among the league elite in that span.

The Red Sox blew a 3-0 lead in this one, the White Sox rallying against Tim Wakefield to take a 4-3 lead on Brent Lillibridge's home run over everything in the sixth. David Ortiz tied it in the bottom of the sixth with his 13th home run and second in two nights, but three singles off Matt Albers, the last by Konerko, put the Chicagoans back in front in the seventh.

The Sox also lost their only left-hander in the bullpen when Rich Hill clutched his elbow after walking Adam Dunn in the seventh and immediately left the game. The Sox called it a left forearm injury and promised further information after the game.

The Sox managed just one hit, a single by Dustin Pedroia, after Ortiz's home run off Gavin Floyd. Relievers Chris Sales and Sergio Santos retired all seven batters they faced.