Rapid reaction: Red Sox 10, White Sox 3

After Chicago White Sox pitcher Philip Humber threw his perfect game Saturday in Seattle, he was invited by late-night talk show host David Letterman to recite a Top 10 list, entitled:

“Thoughts that went through Philip Humber’s mind during his perfect game.’’

Letterman’s writers missed one: “What can I possibly do for an encore?”

The Red Sox provided the answer Thursday night in U.S. Cellular Field in Chicago, and most assuredly, Humber won’t be getting a call from President Obama, a White Sox fan who called after the perfecto, or a text from Tim Tebow.

Mike Aviles, the first batter of the game, walked, which was only the first measure of Humber’s imperfection Thursday night. Kevin Youkilis hit an opposite-field grand slam, one of his three hits, and catcher Jarrod Saltalamacchia hit two home runs in Boston’s 10-3 win over the White Sox on a chilly night in Chicago, where broadcaster Jerry Remy wore gloves with temperatures dipping into the 30s.

With their fourth win in a row, all on this trip, the Sox have pulled to within two games of .500 (8-10). In their last five games, which includes the 15-9 debacle against the Yankees on Saturday, the Red Sox are batting a sizzling .363 (69-for-190) with 10 home runs. They’ve scored 43 runs, an average of more than 8 a game.

Beneficiary of the outburst was lefty Felix Doubront, who recorded his first win of the 2012 season by holding the White Sox to three runs on five hits in six innings. Doubront, who was in line to beat the Yankees until the Sox blew a 9-0 lead last Saturday, walked one, struck out two and gave up a home run to Dayan Viciedo.

Junichi Tazawa came out of the bullpen to give the Sox three innings of two-hit, scoreless relief.