Coach Doug Marrone announced Tuesday that Kyle Orton will once again start Sunday (1 p.m. ET, CBS) for the Bills.
"The game means a lot to me, and we're going to play the best players that we feel give us the best chance to win," Marrone said. "That's just the way that I'm wired and that's what my responsibility is to the team. We all have a responsibility to each other and I have to make those decisions each week."
Orton has a 6-5 record since being named the starter in October. Manuel went 2-2 as the starter in the first four games of the season.
"Right now, we still feel like he gives us the best chance to win from a standpoint of efficiency, control, things of that nature than EJ or Jeff [Tuel] or anyone other quarterback we have," Marrone said.
What does this move mean for Manuel's future with the team?
"I think those things are after the season is over and you look back and you evaluate those things," Marrone said. "I don't think right now I haven't, I haven't put a lot of time into it because we went to correcting the tape and going forward.
"It's not a cliche, guys. I mean it. We're doing everything we possibly can to win this game."
Orton has the ability to void his deal after the season, but is otherwise under contract for next season with a $7 million cap number.
Does Orton have a future in Buffalo?
"Those questions are things that will be discussed offseason," Marrone said. "I have not discussed that with [general manager] Doug [Whaley] or [president] Russ [Brandon] or anyone yet. So it would be hard for me to say and I haven't put too much thought into it.
"I know you guys don't like those answers, but I'm being honest with you."