AFC East Q&A: Which Bill will defenses focus on?

Today's question: The Bills' new-look offense has no shortage of playmakers, from Sammy Watkins and Percy Harvin to LeSean McCoy and Charles Clay. Which one will be the primary focus for the defense you cover?

James Walker, Miami Dolphins: It has to be McCoy. The Bills gave the Dolphins plenty of trouble in recent years. Buffalo is 4-2 against Miami since 2012, and the primary reason is the Dolphins struggled to stop the Bills' rushing attack. From the looks of it, the Bills will run plenty this season. That's in the DNA of both Ryan and new offensive coordinator Greg Roman. Replacing C.J. Spiller with McCoy is a major upgrade, and Fred Jackson also has had good games against Miami. Arguably the Dolphins' biggest weakness is at linebacker, and the Bills' rushing attack will put that position to the test. Miami's defense was 24th against the run in 2014.

Mike Reiss, New England Patriots: A staple of Bill Belichick-coached defenses is working to take away what an opponent does best while exploiting weaknesses. An initial thought with the 2015 Bills, from a Patriots perspective, is that McCoy and the running game would be the focus. Why? To put the ball more in the hands of whoever is playing quarterback, and that's the big question mark for Buffalo. If it's Matt Cassel, the Patriots' win over the Cassel-led Vikings in Week 2 of the 2014 season is a good one to revisit.

Rich Cimini, New York Jets: This one's easy -- Clay. It's not because Clay is better than Watkins, Harvin and McCoy; it's because the Jets have been dreadful when it comes to defending tight ends. They allowed a league-high 14 touchdowns by tight ends in 2014. Any tight end with a pulse was a threat. They signed free safety Marcus Gilchrist, but he doesn't have a lot of experience covering No. 1 tight ends. Strong safety Calvin Pryor isn't known for his man-to-man coverage. As for the Bills' other weapons, the Jets match up nicely. With Darrelle Revis and Antonio Cromartie at corner, they shouldn't be sweating Watkins and Harvin. McCoy is a threat, no doubt, but the Jets have a strong group of run-stoppers, led by nose tackle Damon Harrison. They shouldn't have any issues with the Bills' suspect offensive line.