Coach Rex Ryan said after the game that Easley suffered a Grade 1 injury to his medial collateral ligament.
"We will see how those things work," Ryan said. "My understanding is none of them are serious, unless you are the person obviously. But none of them seem to be too bad and hopefully that's right."
The injuries thin the Bills' depth along the defensive line, at least in the short term. Pro Bowl defensive tackle Kyle Williams missed Friday's game with a bruised quad while top reserve linemen Alex Carrington and Stefan Charles also were out because of injuries suffered in practice this week.
Bryant and Wynn are key reserves along the defensive line, with Bryant the favorite to start in place of Marcell Dareus, who is suspended for the first game of the season.
Kick returner Marcus Thigpen had an ankle injury that Ryan said was "not serious."