The Buffalo Bills arrived Wednesday evening in Cleveland with a 90-man roster depleted by injuries, particularly at running back.
Coach Rex Ryan said Tuesday that his team will "absolutely be limited" with its offensive play-calling in Thursday's preseason tilt (8 p.m. ET, ESPN) with the Browns, partly because of an inexperienced group of running backs that features two players -- Ricky Seale and Cierre Wood -- who were signed this week.
Seale and Wood will be among five new faces who are likely to play in Thursday's game, along with linebacker Quentin Groves, defensive tackle Red Bryant and cornerback Ellis Lankster -- all signed since last Friday's preseason loss to the Carolina Panthers.
Which Bills players won't be suiting up for the game? Here are my best educated guesses:
Don't expect them to play:
RB LeSean McCoy, RB Fred Jackson and RB Bryce Brown -- All three of these backs have hamstring injuries. Jackson and Brown could return for the Bills' preseason game against Pittsburgh on Aug. 29 but McCoy is almost certainly out for the remainder of the preseason.
RB Boobie Dixon -- Dixon has been out since Aug. 3 with a calf injury. Like Brown and Jackson, the Bills are going to try to get him back for the Steelers game but will still play it safe. He should be ready for the regular season.
RB Karlos Williams -- The rookie underwent a medical procedure Monday and is out at least two weeks, which essentially rules him out for the remainder of the preseason.
WR Percy Harvin -- Harvin has been out since Aug. 12 and will be out at least another week after getting a PRP injection for his sore hip. He's dealt with hip issues in the past, so there might start to be some concern that it will linger into the regular season. Harvin has been trying to get back on the field but his hip isn't responding to treatment as well as the Bills hoped.
DL Alex Carrington -- He hasn't practiced since early last week because of a shoulder issue. With Jarius Wynn (ACL) out for the season, Carrington is the Bills' top backup behind Mario Williams and Jerry Hughes. Who's the next man up? IK Enemkpali.
WR Marcus Easley -- The Bills' special teams ace suffered a Grade 1 MCL injury in last Friday's game and didn't practice this week.
LB Jimmy Gaines -- Gaines hasn't practiced in over a week because of an apparent arm injury. With Ty Powell (ACL) out for the season, expect Tony Steward and AJ Tarpley to get extended playing time Thursday.
CB Ross Cockrell -- Last year's fourth-round pick has been out with a knee injury suffered in the Bills' intrasquad scrimmage Aug. 8. He was spotted on the sidelines Tuesday doing some rehab work with the strength and conditioning staff, which is a good sign for him.
Iffy if they'll play:
DT Kyle Williams -- Williams is a sturdy, tough player who will probably want to play Thursday night after returning to practice Tuesday. Whether he actually suits up is unclear. Williams missed over a week after bruising his quad Aug. 10. Williams is a key piece to the Bills' defense and they'll need him healthy all season, so it doesn't make sense to push it for a preseason game.
WR Sammy Watkins -- The Bills are playing it safe with Watkins, who has sat out various parts of training camp with soreness, most recently in his glute area. Rex Ryan keeps using the word "precaution" with Watkins and it wouldn't be surprising if he sits Thursday night for precautionary reasons.
WR Robert Woods -- Woods was ready to practice Tuesday but returned to the locker room and came back out in street clothes. He was apparently sore from a heavy workload Monday. He seems more likely than Watkins or Williams to play Thursday night.