8:15 p.m. ET | ESPN
Matchup rating: 49.6 | Spread: MIN -2.5 (44.5)
What to watch for: Bears coach Matt Nagy is under tremendous pressure to fix the league's worst offense, but he is 4-0 versus the Vikings since he took over in 2018 and 2-1 overall on Monday Night Football. For Nagy's steak against Minnesota to continue, Chicago's offense needs a wakeup call. The Bears average an abysmal 19.8 points and 82.6 rushing yards per game, and they rank 31st in third-down conversion (32.3%) and yards per play (4.81). On the flip side, the Vikings have allowed opponents to score 30-plus points on three separate occasions in 2020. -- Jeff Dickerson
Bold prediction: Vikings running back Dalvin Cook is going to face a ton of loaded boxes, so it's possible the Vikings will have to get into a dropback game with quarterback Kirk Cousins to win this one. The Bears' defense knows how to exploit Minnesota's weaknesses and will do so by sacking Cousins five times and not allowing him to complete a pass over six yards downfield. -- Courtney Cronin
Stat to know: Cousins is 0-9 in his career on Monday Night Football, the most consecutive losses by a starting QB to begin career on MNF and the longest losing streak by a starting QB in MNF history.
What to know for fantasy: The Saints' Drew Brees and Alvin Kamara have been great, right? Over the past two weeks, they've racked up 83.5 points between them. Well, over that stretch, Cook has 87.8 points ... by himself. See Week 10 rankings.
Betting nugget: All five NFC North divisional games have gone over the total this season, after they were 9-3 to the under last season. Read more.
Cronin's pick: Bears 20, Vikings 17
Dickerson's pick: Vikings 21, Bears 16
FPI prediction: MIN, 59.1% (by an average of 3.1 points)