Romo, 36, has started 16 games in four of his nine full seasons as the Cowboys' starter. He took over in Week 7 of the 2006 season and started 55 of the next 58 games. In 2011 and '12, he started every game as well.
In 2011, he suffered a broken rib and punctured lung against the San Francisco 49ers, but he did not miss a game.
Here is a look at Romo's injuries over the years that have forced him to miss games:
2008 -- Broken right pinkie finger. He missed three games that ultimately cost the Cowboys a chance at making the playoffs. They went 1-2 without Romo and lost a winner-take-all season finale at the Philadelphia Eagles. After that game, Romo collapsed in the shower because of a rib injury.
2010 -- Broken left collarbone. He suffered the injury in the first half against the New York Giants when fullback Chris Gronkowski failed to pick up linebacker Michael Boley. Romo missed 10 games but was not placed on injured reserve until the second-to-last week of the season. The Cowboys went 5-5 in Romo's absence with Jon Kitna winning four times and Stephen McGee once.
2013 -- Ruptured disk. Romo missed a winner-take-all meeting in Week 17 against the Eagles after undergoing a discectomy two days before the game. Romo actually suffered the injury in a thrilling 24-23 win against the Washington Redskins in which he delivered the game-winning touchdown pass on fourth down. With Kyle Orton starting, the Cowboys lost to the Eagles 24-22.
2014 -- Two transverse process fractures. He missed the Nov. 2 meeting against the Arizona Cardinals after he was kneed in the back by Washington linebacker Keenan Robinson. He returned for the final two series after X-rays were negative. Brandon Weeden started against the Cardinals, and the Cowboys lost 28-17.
2015 -- Broken left collarbone. Romo suffered the injury in the second game of the season when he was sacked by Eagles linebacker Jordan Hicks, who landed on top of him in the third quarter. The Cowboys beat Philadelphia but lost the next seven games with Weeden and Matt Cassel as their starting quarterbacks.
2015 -- Broken left collarbone. In his second game back, Romo was knocked out on the final play of the third quarter, when he was sacked by Carolina Panthers linebacker Thomas Davis. While Romo's previous fractures had healed, he suffered a re-break in the healed portion. He missed the final five games of the season. The Cowboys won just once (at Washington) without Romo all season.
2016 -- Compression fracture, L1 vertebra. On the third play of Thursday's preseason game against the Seattle Seahawks, Romo was driven into the turf while sliding by defensive end Cliff Avril. After the game, Romo said he felt good and Jerry Jones said he expected Romo to be ready for the regular-season opener. Romo had an MRI on Friday, which showed the break. A source said he is looking at a 6-10 week recovery period. Rookie Dak Prescott will start in Romo's absence.