4:25 p.m. ET | FOX
Matchup rating: 54.8 | Spread: TB -6 (43.5)
What to watch for: C'mon, it's Tom Brady. Now that he's moved to the NFC, this might be his last game in Denver, where Brady faces a statistical quirk in his storied career -- the Broncos are the only team he does not have a winning record against. He has faced the Broncos 17 times in his career and is 8-9 overall against them (7-6 in the regular season, 1-3 in the playoffs). It will be a struggle for the injury-ravaged Broncos to keep Brady from getting back to .500, but to have any shot at stopping him, they will have to find a way to generate more of a pass-rush. Denver cranked up five-man rush packages just four times against the Steelers last week and surrendered touchdowns on two of those plays. -- Jeff Legwold
Bold prediction: The Buccaneers will notch five more sacks this week, with three coming from Shaquil Barrett. Champing at the bit for his first sack of 2020 and returning to Mile High as the 2019 sack champion, the former Bronco has been primarily rushing from the left side this year, and right tackle Elijah Wilkinson has had 4.0 sacks against attributed to him in two games -- more than any other player in the league. -- Jenna Laine
Stat to know: Denver tight end Noah Fant is averaging 14.3 yards per reception since entering NFL in 2019, a rate that ranks second among tight ends in that time (Jared Cook, 16.0). He could become the first Broncos player with a receiving TD in three straight games since Demaryius Thomas did it in 2017.
What to know for fantasy: The Buccaneers D/ST ranks eighth in fantasy points this season, and the Broncos are allowing pressure at the third-highest rate. See Week 3 rankings.
Betting nugget: The over has hit in 14 of the last 16 Buccaneers games. Read more.
Laine's pick: Buccaneers 31, Broncos 18
Legwold's pick: Buccaneers 24, Broncos 16
FPI prediction: TB, 57.8% (by an average of 2.8 points)
Matchup must-reads: Gronkowski's ultimate Florida road trip: A guided tour with festivals, mermaids and manatees ... Broncos challenged by injuries just 19 days removed from optimism ... Godwin clears concussion protocol; no RB change ... Who is new Broncos' starting quarterback Driskel?