The entire schedule will be released at 8 p.m. ET (7 p.m. CT).
The Packers have played on Thanksgiving six times since the 2001 season, including every other year since 2007, but they have all been in the traditional early game at the Detroit Lions.
It will mark the first time the Packers have hosted a game on Thanksgiving since 1923.
The NFL added a third game on Thanksgiving in 2006. Unlike the traditional early game at Detroit and afternoon game at Dallas, the prime-time game rotates sites.
The Packers and Bears last played on a major holiday on Christmas day in 2011 at Lambeau Field.
The Thanksgiving night game could be when the Packers put Brett Favre's retired No. 4 up on the stadium façade. Favre (pictured) will have his number retired during his July 18 induction into the Packers Hall of Fame.
Last week, Packers president Mark Murphy said he asked the league for special scheduling consideration with regard to Favre's ceremony, but wouldn't specify what was in the request. However, Favre's agent, Bus Cook made reference to a November date during an interview at the scouting combine. Cook also said he hoped it would be when the Packers played the Bears.