Not that it came easy.
The story has been told about how hard Osweiler worked this offseason to learn the Texans' offense. O'Brien and offensive coordinator George Godsey's scheme is complex, and several players have said it took them more than a year to truly "get it."
But Osweiler didn't have that long. Not after he signed a four-year, $72 million contract in March. There were high expectations after general manager Rick Smith and owner Bob McNair gave Osweiler such a big contract.
So Osweiler spent his spring and summer in the film room and with his playbook.
"There's a lot of time and a lot of effort, not only on the practice field, but outside of this building, that he's putting in," Godsey said.
And on Tuesday, O'Brien said he has been very impressed by the way Osweiler leads the Texans' offense.
"I think one of the things that we've seen that, to me, has been very impressive and has to continue during the season is his command of the offense," O'Brien said. "When we watch the tape … one of the things that stands out to me, personally, is his knowledge and his command of the offense.
"That has to continue to improve and it has to -- we can't take a step back with that -- and I think that's something that he does really well. That's what I would like to really see him continue to do when the season starts."
Teammates have said Osweiler is a vocal leader in a huddle, and after Sunday's 34-24 victory over the Cardinals, wide receiver Cecil Shorts III said he has been impressed by the quarterback's leadership and his communication.
"He's on top of it," Shorts said. "It's not surprising because he's studying his butt off each and every day. He's prepared. He knows his job, and he knows everybody else's job. As a quarterback, your responsibility is a lot."
No one knows that more than Osweiler, which why is he worked so hard this offseason to get to this point.
"He has a 'coach me, coach' attitude," Godsey said. "[I] really appreciate the way he comes in every day. He asks questions. Even if it's something that we've discussed very briefly, he has questions on some of that that he knows that at one point, it's going to come up, and it's going to be a big play in a game. Can't ask for any more from the amount of time he's put in."