4:25 p.m. ET | CBS
Matchup rating: 75.4 | Spread: BAL -7 (52)
What to watch for: Will Lamar Jackson and Deshaun Watson continue to have success on the run? Both rushed for seven touchdowns in 2019, but they also each scored eight touchdowns (with no interceptions) when passing on the run, according to ESPN Stats & Information. Only then-Buccaneers quarterback Jameis Winston threw more touchdowns on the run last season. -- Sarah Barshop
Bold prediction: Baltimore's Jackson will rush for at least 100 yards. He showed in Week 1 that he has made great strides as a passer, but let's not forget he's among the league's most dangerous playmakers when scrambling. The Texans have allowed quarterbacks to average 5.6 yards per rush since the start of 2019, which is the second-worst over that span. Last season, Jackson ran for 79 yards against Houston, including a 39-yard run (which was his second-longest of the season). -- Jamison Hensley
Stat to know: Per the Elias Sports Bureau, the 2020 Texans are the second team in NFL history to face the reigning MVP and Super Bowl MVP in each of its first two games of a season (faced Patrick Mahomes in Week 1). The 2004 Colts are the other, as they faced Tom Brady (Super Bowl MVP) and Steve McNair (MVP) to open their year. They started 1-1 and finished 12-4.
What to know for fantasy: 250 passing yards, 25 rushing yards, a passing touchdown and a rushing touchdown. Watson led the NFL with two such games in 2018, led again in 2019 with three such games and was one of two quarterbacks (Josh Allen) to accomplish the feat in Week 1 this season. See Week 2 rankings.
Betting nugget: The Ravens have covered in five straight regular-season games, and 10 of their last 11. Read more.
Hensley's pick: Ravens 30, Texans 27
Barshop's pick: Ravens 34, Texans 23
FPI prediction: BAL, 68.5% (by an average of 6.9 points)
Matchup must-reads: Three ways Jackson is better than his MVP season ... Texans had tackling issues in opener, and here comes Lamar Jackson ... Texans must quickly figure out what went wrong ... Texans squander chance to show they can thrive without Hopkins