1 p.m. ET | CBS
Matchup rating: 44.3 | Spread: NE -2.5 (48.5)
What to watch for: Patriots cornerback J.C. Jackson has intercepted a pass in five consecutive games, the longest streak since Reggie Nelson in 2015. According to research by ESPN Stats & Information, if Jackson intercepts a pass on Sunday, he would match the longest interception streak since the 1970 AFL-NFL merger, done most recently by Brian Russell in 2003. But while Texans quarterback Deshaun Watson has thrown five interceptions this season, he hasn't thrown one since Week 5. -- Sarah Barshop
Bold prediction: New England running back Damien Harris will rush for 200 yards against the NFL's 32nd-ranked rush defense. The Texans are allowing an average of 167.4 rushing yards per game, which means quarterback Cam Newton and a Patriots offense that has transformed itself into a power-running machine have a chance to feast. -- Mike Reiss
Stat to know: The Patriots have a 75.7 offensive efficiency over the past three weeks, fourth in the NFL during that span. It's a vast improvement from the team's 44.1 offensive efficiency in the first seven weeks (27th). Newton, who is seeking his first three-game win streak as a starting quarterback since Weeks 7-9 of 2018, has a 76.9% completion percentage over his past two games -- tops in the league over that time.
What to know for fantasy: Complaining about the Patriots' backfield in fantasy needs to stop. Over the past month, Harris has accounted for 74% of New England's RB rushing yards and faces fantasy's worst run defense in terms of stopping running backs. See Week 11 rankings.
Betting nugget: Houston is 2-7 ATS this season, tied with the Jets for the second-worst ATS mark in the NFL. Read more.
Reiss' pick: Patriots 24, Texans 20
Barshop's pick: Texans 24, Patriots 20
FPI prediction: NE, 51.3% (by an average of 0.5 points)
Matchup must-reads: Belichick's hoodies explained: A visual history of the Patriots coach's most memorable looks ... Against Browns -- and in 2021 -- the Texans have no solid answer at running back ... NFL interception leader Jackson added to Pro Bowl ballot after initial omission ... Texans RB Johnson goes on IR ... Newton after upset win: Patriots can show they're better than 4-5