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A look at the Colts' Week 1 opponent: Buffalo Bills

INDIANAPOLIS – The Indianapolis Colts are supposed to have a lot of success this season based off their schedule.

On paper.

Yes, they play in the AFC South, one of the worst, if not the worst, divisions in the NFL. They also play the NFC South, which had a team with a losing record – Carolina – make the playoffs last season, and the AFC East, which had only New England make the playoffs last season.

But each season brings changes to rosters.

We’re going to take a look at the Colts’ week-by-week opponents for the 2015 season starting with the Buffalo Bills.

2014 record: 9-7

Key additions: DE Alex Carrington, TE Charles Clay, FB Jerome Felton, FB John Conner, WR Justin Brown, WR Percy Harvin, G Richie Incognito, QB Tyrod Taylor, QB Matt Cassel, RB LeSean McCoy

Key subtractions: ILB Brandon Spikes, RB C.J. Spiller, OT Chris Hairston, S Da'Norris Searcy, OG Erik Pears, ILB Keith Rivers, QB Kyle Orton, OLB Larry Dean, TE Lee Smith, TE Scott Chandler, OLB Stevenson Sylvester, LB Kiko Alonso

First-round draft pick: None

Area of concern for the Colts: The Bills brought Rex Ryan and his defensive reputation. Buffalo finished fourth in the league in total defense last season. Ryan will have an impressive front seven, which includes former Colt Jerry Huhes, to work with. Offensively, Buffalo acquired running back LeSean McCoy from Philadelphia. McCoy had 19 rushes for 79 yards and a touchdown to go with four receptions for 23 yards against the Colts last season.

Area that favors the Colts: McCoy could give the Colts problems, but the Bills have questions at quarterback. Tyrod Tayler and the veteran Matt Cassel will challenge EJ Manuel for the starting job. The NFL is a quarterback-driven league and Buffalo, at this moment, doesn’t have a dependable quarterback on its roster. The Bills will be without a two-time Pro Bowler against the Colts. Defensive tackle Marcell Dareus has been suspended for a game for violating the NFL’s substances abuse policy. The suspension bodes well for Colts quarterback Andrew Luck and running back Frank Gore.