1 p.m. ET | Fox
Matchup rating: 50.1 | Spread: IND -3 (48)
What to watch for: Colts cornerback Xavier Rhodes faces his former team after being released by the Vikings in the offseason following seven seasons with the franchise. Rhodes' debut with the Colts didn't go too well in Week 1 against Jacksonville. He gave up a 22-yard touchdown when he was caught peaking in the backfield expecting a run. Then he was flagged for 30-yard pass interference, which ended up leading to a field goal for the Jaguars. Can he improve while trying to contain Minnesota's passing attack? -- Mike Wells
Bold prediction: Vikings receiver Adam Thielen will haul in seven catches for 120-plus yards. It'll be his second straight week crossing the century mark, putting him on his way to matching the historic streak he set in 2018 when he started the season with eight straight 100-yard receiving performances. -- Courtney Cronin
Stat to know: Colts quarterback Philip Rivers has four passing touchdowns, seven interceptions and a 1-3 record in four career starts against the Vikings. And his 35.1 Total QBR against them is his worst against any team since the metric was first tracked in 2006.
What to know for fantasy: Indianapolis receiver Parris Campbell not only set career-highs in routes (38), targets (9), catches (6), yards (71) and fantasy points (14) in Week 1, but he also led the team in deep targets (3). See Week 2 rankings.
Betting nugget: The Vikings have covered their last five games after a loss. Read more.
Cronin's pick: Colts 28, Vikings 24
Wells' pick: Colts 27, Vikings 23
FPI prediction: IND, 51.4% (by an average of 0.6 points)
Matchup must-reads: Life without Diggs? Vikings run out of time to see new reality ... Colts lose Mack for season with torn Achilles ... Colts sad for Mack, excited about Taylor ... Rivers brings turnover problems to Colts in Week 1